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This results in down-regulation of target expression, at either the transcript or the translational level (Baek et al. However, decades of molecular studies on transcription factors have revealed that their actions are largely combinatorial, i.e., their specific effect—activation or repression of gene expression—is strictly dependent on the local chromatin microenvironment, which in turn is an expression of the combination of multiple factors, such as cell type and a plethora of internal and external stimuli.

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