Activating or sedating ssri

25-Jan-2020 02:25 by 10 Comments

Activating or sedating ssri

An adult with depression who is responding to antidepressant treatment should normally continue to take the antidepressant for at least 6 months after remission (not just after the initial response) of an episode of depression in order to reduce the risk of relapse.

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Some improvement is usually seen within two weeks of starting antidepressant treatment at a therapeutic dose.

Treatment resistant cases should be referred to secondary care.

SSRIs are better tolerated and are safer in overdose than other classes of antidepressants.

No single SSRI has a significantly better safety or effectiveness.

If the first SSRI tried is not tolerated or does not work it is reasonable to try another SSRI.

Starting dose can be 10 mg of citalopram, fluoxetine or paroxetine.

After a week, if the patient tolerates the medication, the dose can be increased.The evidence suggests that it works at least in moderate depression but maybe less effective in severe depression.It provides an option when the patient is unable to tolerate anything else.Dose titration for both SSRIs and TCAs is usually slower for anxious patients as they appear more sensitive to side effects.It is not unusual for anxious patients to have more anxiety during the titration of SSRIs.Higher doses are necessary for treatment of obsessive compulsive disorder.

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